Simultaneous spectrophotometric determination of trimethoprim and sulphamethoxazole following charge-transfer complexation with chloranilic acid
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چکیده
منابع مشابه
Spectrophotometric Determination of Astemizole and Loratadine Based on Charge-Transfer Complex Formation with Chloranilic Acid
A simple and sensitive spectrophotometric method for the assay of two antihistamines, astemizole and loratadine, is described. The determination was based on the formation of chargetransfer complexes between chloranilic acid as a p acceptor and the studied drugs as n-donors in acetonitrile solvent. The spectra, various experimental parameters, composition and formation constant of the complexes...
متن کاملSpectrophotometric determination of atropine, pilocarpine and strychnine with chloranilic acid.
In dioxan-chloroform medium the acceptor chloranilic acid forms 1:1 molecular complexes with the alkaloids atropine, pilocarpine and strychnine, with maximum absorption at 535, 527.5 and 535 nm respectively. Conformity with Beer's law allows the use of the complexes for the assay of these drugs.
متن کاملSpectroscopic analytical study for the charge-transfer complexation of certain cephalosporins with chloranilic acid.
Studies were carried out to develop a simple, rapid and accurate spectrophotometric method for the analysis of fifteen cephalosporins. The method depends on the charge-transfer complexation reaction between any of these drugs as an n-electron donor and p-chloranilic acid (p-CA) as a pi-acceptor to form a violet chromogen measured at 520 nm. Different variables affecting the reaction were studie...
متن کاملDetermination of Trimethoprim Based on Charge-Transfer Complexes Formation
A spectrophotometric study concerning the interaction between Trimethoprim (TMP) ,Sulfamethoxazole (SFMx), as n-donor and 2,3-dichloro-5,6- dicyano-P-benzoquinine (DDQ) and chloranilic acid (CA) as π-acceptor were been performed at 25°C. The results of interaction of CA and DDQwith TMP indicate the formation of a 1:1, 1:2, charge transfer complexes through non equilibrium reactions. In the case...
متن کاملSpectrophotometric determination of sulphamethoxazole and trimethoprim (co-trimoxazole) in binary mixtures and in tablets.
BACKGROUND The formulation of sulphamethoxazole (S) and trimethoprin (T) (CO-TRIMOXAZOLE) in a combination mixture is very good pharmacologically since it enhances the efficacy of the individual drugs. However in this combination, difficulties in analysis on ordinary UV spectrophotometry are introduced because the two components give overlapping spectral bands on zero-order. The United States P...
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ژورنال
عنوان ژورنال: Arabian Journal of Chemistry
سال: 2017
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2014.05.022